IMMUNOLOGICAL STATUS OF CHILDREN AND ADOLESCENTS WITH JUVENILE IDIOPATHIC ARTHRITIS ON A BACKGROUND OF THE THERAPY TAKEN 

Tepikina Ekaterina Nikolaevna, Postgraduate student, Samara State Medical University, semenukova@rambler.ru

616.72-002:612.017-053.2-08

The article introduces the results of immunological study of 58 patients with juvenile idiopathic arthritis. The author has detected substantial changes of cytokine status in serum and synovial fluid in all forms of the disease, with a degree of severity depending on the variant and the activity of the inflammatory process. The study of cellular immunity has been conducted in order to establish a differentiated approach to the choice of therapy, and caused be the differences in drug efficiency depending on the variant of the disease. The greatest efficiency of the treatment of polyarticular and oligoarticular spreading form has been observed in remicade; combined therapy with sandimmun-neoral and methotrexate is preferable to use at oligoarticular persistent form of juvenile idiopathic arthritis.

 juvenile idiopathic arthritis, interleukin-17, remicade.